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PRESENTING THE UNCERTAINTY OF SAMPLE SIZE CALCULATIONS Eddie Channon, Chirostat Statistical Consulting PSI conference May 2007 ABSTRACT As an example, when proportions on treatment and placebo were estimated from a reference study in 80 patients, the proposed sample size for the new study had power ranging from 50% to 100% (average 90%). After seeing these calculations, the clinician identified additional reference studies which led to much more precise sample size calculations. A second example looks at the uncertainty when standard deviation has been estimated from a small reference study. . . . .
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